Economic evaluation of a phase III international randomised controlled trial of very early mobilisation after stroke (AVERT)

L Gao; L Sheppard; O Wu; L Churilov; M Mohebbi; J Collier; J Bernhardt; F Ellery; H Dewey; M Moodie

Journal article

Economic evaluation of a phase III international randomised controlled trial of very early mobilisation after stroke (AVERT)

L Gao, L Sheppard, O Wu, L Churilov, M Mohebbi, J Collier, J Bernhardt, F Ellery, H Dewey, M Moodie

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019

DOI: 10.1136/bmjopen-2018-026230

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Abstract

Objectives While very early mobilisation (VEM) intervention for stroke patients was shown not to be effective at 3 months, 12 month clinical and economical outcomes remain unknown. The aim was to assess cost-effectiveness of a VEM intervention within a phase III randomised controlled trial (RCT). Design An economic evaluation alongside a RCT, and detailed resource use and cost analysis over 12 months post-acute stroke. Setting Multi-country RCT involved 58 stroke centres. Participants 2104 patients with acute stroke who were admitted to a stroke unit. Intervention A very early rehabilitation intervention within 24 hours of stroke onset Methods Cost-utility analyses were undertaken according ..

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University of Melbourne Researchers

Leonid Churilov Author

Julie Bernhardt Author

Related Projects (2)

AVERT: A large, international, randomised controlled trial testing efficacy and cost effectiveness of early and frequent mobilisation after stroke

AVERT is a large, international clinical trial that tests whether introducing early and frequent exercise helps reduce the unacceptably high..

RESEARCH FELLOWSHIP

Stroke affects 1 in 6 Australians and often leads to lifelong disability. This Fellowship will support A/Prof Bernhardt to: 1) complete the ..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The economic evaluation component of the AVERT study was funded by the National Health and Medical Research Council (NHMRC) of Australia (grant numbers 386201 and 1041401). Additional funding was received from Singapore Health (SHF/FG401P/2008), Chest Heart and Stroke Scotland (Res08/A114), Northern Ireland Chest Heart and Stroke and the Stroke Association UK (TSA2009/09). NHMRC fellowship funding was provided to HD (336102) and JB (1058635). JB was also supported by an Australia Research Council Future Fellowship (IFT0991086) and the National Heart Foundation. The Florey Institute of Neuroscience and Mental Health acknowledges the support received from the Victorian Government via the Operational Infrastructure Support Scheme. The content of the publication is solely the responsibility of the authors and does not reflect the views of the funders.